ABC-SEPSIS trial for albumin in septic shock

Nov 01, 2024

∙ Paid

Neither of two large randomized trials in the 2000s showed a benefit from albumin solutions as a resuscitation fluid for patients with septic shock.

Significant uncertainty remained, though, as we discussed further here:

Albumin as resuscitation fluid for septic shock: Review

PulmCCM

Oct 14

Albumin as resuscitation fluid for septic shock: Review

Albumin is a protein produced by the liver whose molecular weight and negative charge attract sodium cations, and with them water molecules. In this way albumin produces most of the vascular system’s oncotic pressure—the force tending to retain fluid in blood vessels without its leaking into the extravascular space. This increases mean arterial pressure.

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Another randomized trial was therefore performed, dubbed ABC-SEPSIS.

ABC-SEPSIS Trial

The ABC-SEPSIS trial (Gray et al Crit Care Med 2024…

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