Are usual vasopressor doses causing unrecognized harm?

Two meta-analyses suggest "permissive hypotension" might save lives in vasodilatory shock

Maintaining a mean arterial pressure (MAP) of 65 mm Hg has been advised for patients with sepsis and other forms of vasodilatory shock. In practice, treating teams often exceed this target by a significant margin, such as in patients with more severe organ failure or pre-existing hypertension. This strategy is likely pursued out of concern that lower MA…