Ceftriaxone for all vented brain injured patients? (PROPHY-VAP)

Patients with strokes and traumatic brain injuries who require mechanical ventilation due to coma are at very high risk for developing ventilator associated pneumonia. Prophylactic antibiotics, given enterally or intravenously, have been shown to reduce the rate of VAP, but with unproven clinically meaningful benefits like survival. Secondary consequenc…