Chronic rhinosinusitis: oral steroid "priming" helped

Valdyanathan et al gave prednisolone 25 mg (equivalent to prednisone) or placebo daily for 2 weeks to sufferers of chronic rhinosinusitis in the UK, followed by 8 months of nasal fluticasone (drops, then spray) for all. The orally-treated group had a 2.1-point fall in their polyp grade and could smell better, at 6 months. Ann Int Med 2011;154:293-302.