Continuous antibiotic infusions for sepsis: do they save lives?

A large meta-analysis suggests benefits of prolonged beta-lactam infusions

Beta-lactam antibiotics are the most often-prescribed antimicrobials for sepsis in the ICU, with piperacillin-tazobactam, cefepime and meropenem being the most common.

Although they are usually administered in short-duration infusions, continuous infusions can maintain circulating levels of antibiotics at higher concentrations, killing microorganisms for…