Continuous meropenem infusion for critically ill patients with sepsis (MERCY trial)

Antibiotics have a time-dependent effect on bacteria, so maintaining bacteriocidal concentrations of antibiotics should theoretically help subdue infections better than intermittent dosing. A 2018 meta-analysis reviewed here suggested that prolonged infusion of antipseudomonal beta-lactams reduced mortality by 30% compared with shorter infusions, and mo…