Corticosteroids for ischemic stroke (MARVEL trial)

Findings of reduced mortality and disability require replication

While outcomes from acute ischemic stroke due to large vessel occlusion in the anterior circulation have improved substantially in the era of thrombolytics and mechanical thrombectomy, overall outcomes remain poor. 

Studies in animal models have suggested corticosteroids might reduce infarct size or extension of subsequent cerebral edema. When tested pre…