Do PPIs for stress ulcer prophylaxis cause death in the sickest patients?

2024 meta-analysis revives concerns about PPIs' risks

After decades of uncertainty, the REVISE trial (Cook et al NEJM 2024) established that proton pump inhibitors as stress ulcer prophylaxis (SUP) reduce significant gastrointestinal bleeding in mechanically ventilated patients compared to placebo (1% vs. 3.5%, highly significant).

Stress ulcer prophylaxis in the ICU: Review

There was no significant difference in adverse events between groups (in mor…