Do thrombolytics improve outcomes in less severe strokes?

TEMPO-2, testing TNK vs antiplatelets, may have decided things

Thrombolysis with alteplase (tPA) or tenecteplase (TNK) has become standard care for moderate-to-severe ischemic strokes presenting within 4.5 hours of symptom onset, followed by mechanical thrombectomy in cases of large vessel occlusion in the anterior circulation.

Patients with the mildest strokes were excluded from the trials that established the bene…