Empiric antibiotics for HCAP/VAP were appropriate - yet deadly?
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In a well-intentioned performance improvement initiative, Daniel Kett and the IMPACT-HAP team prospectively observed 303 patients at risk for MDR pneumonia at four academic hospitals. Surprisingly, more of those who got appropriate antibiotics died (34%) than those treated off-ATS/IDSA guidelines (20%), with Kaplan-Meier-modeled 28-day survival of 65% vs. 79%, p=0.0044. The authors were concerned enough to recommend against continued adherence to ATS/IDSA HCAP antibiotic guidelines, pending a randomized trial. The study was funded by Pfizer, who have been reported to be
Empiric antibiotics for HCAP/VAP were appropriate - yet deadly?
Empiric antibiotics for HCAP/VAP were…
Empiric antibiotics for HCAP/VAP were appropriate - yet deadly?
In a well-intentioned performance improvement initiative, Daniel Kett and the IMPACT-HAP team prospectively observed 303 patients at risk for MDR pneumonia at four academic hospitals. Surprisingly, more of those who got appropriate antibiotics died (34%) than those treated off-ATS/IDSA guidelines (20%), with Kaplan-Meier-modeled 28-day survival of 65% vs. 79%, p=0.0044. The authors were concerned enough to recommend against continued adherence to ATS/IDSA HCAP antibiotic guidelines, pending a randomized trial. The study was funded by Pfizer, who have been reported to be