For empyema, tPA plus DNAse in the pleural space improved outcomes (RCT, NEJM)
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More than 65,000 people develop empyema each year, and 25% of them are in the hospital a month or longer. Past randomized trials and a meta-analysis showed streptokinase didn't help, but case series suggested tissue plasminogen activator might. Rahman
For empyema, tPA plus DNAse in the pleural space improved outcomes (RCT, NEJM)
For empyema, tPA plus DNAse in the pleural…
For empyema, tPA plus DNAse in the pleural space improved outcomes (RCT, NEJM)
More than 65,000 people develop empyema each year, and 25% of them are in the hospital a month or longer. Past randomized trials and a meta-analysis showed streptokinase didn't help, but case series suggested tissue plasminogen activator might. Rahman