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Gabapentin enacarbil for restless legs syndrome (PIVOT RLS II trial)

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Gabapentin enacarbil for restless legs syndrome (PIVOT RLS II trial)

Jun 3, 2011
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Lee et al report phase III trial results for this prodrug of gabapentin. It improved symptoms in people with moderate-to-severe RLS at the end of 12 weeks, compared to placebo. However, time (placebo) also worked well. The FDA approved the drug for moderate-to-severe RLS in April 2011. J Clin Sleep Med 2011;7:282-292.

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