Haldol is safe and may be beneficial for hyperactive delirium in the ICU

AID-ICU trial finds surprising mortality benefit for haloperidol

Antipsychotics have been overused in hospitalized patients, in and out of ICUs. After the 2018 MIND-USA trial found neither haloperidol nor ziprasidone reduced delirium in the ICU, critical care guidelines advised against their wide use. But about 90% of the MIND-USA patients had hypoactive delirium, without agitation. The recommendations had the effect…