Higher vs. lower oxygenation targets in Covid-19 (HOT-COVID trial)

Published in January 2021, the HOT-ICU trial found no difference in mortality (42.9% vs 42.4%) among 2928 hypoxemic patients in European ICUs receiving at least 10L/min oxygen, regardless of whether they were randomized to a high (PaO2 90 mmHg) or low (PaO2 60 mmHg) oxygenation target. Nor were there any significant between-group differences in need for…