Jon-Emile S. Kenny MD [@heart_lung] with illustrations by Carla M Canepa MD [@_carlemd_] “I've never known any trouble than an hour's reading didn't assuage.” -Schopenhauer The last few decades have infamously boasted numerous failed therapies for sepsis and septic shock. Because sepsis represents an explosive and chaotic cacophony of pro and anti-inflammatory mediators – treatments which are overly specific are unlikely to silence a dissonant septic crescendo. This may be akin to removing a single musician from a poorly orchestrated symphony; a more harmonious intervention may be to replace the conductor.