Is procalcitonin "safe" to guide antibiotic use in patients with sepsis?

ADAPT-Sepsis tests the strategy in the U.K., with global ambitions

Many randomized trials have tested the biomarker procalcitonin as a guide to de-escalate or stop antibiotic therapy in patients with known or suspected infection. A large proportion have concluded PCT is a safe and effective method to shorten antibiotic courses, including in patients with sepsis.

But most such trials have been small, often single-center…