NIV (BiPAP) for preoxygenation before intubation prevented hypoxemia and cardiac arrest (PREOXI trial)

Compared to nonrebreather oxygen masks in the control group

A large randomized controlled trial found significant reductions in hypoxemia and cardiac arrest among critically ill patients undergoing rapid sequence intubation who received noninvasive ventilation during the preoxygenation and apneic phases of RSI.

The PREOXI trial enrolled 1,301 adults at seven emergency departments (27% of the intubations) and 17 …