Piperacillin-Tazobactam vs. Cefepime for Kidney Injury and Neurologic Dysfunction (ACORN Trial)

Piperacillin-tazobactam, marketed as Zosyn, has been one of the most-prescribed broad spectrum antibiotics for many years, used for its bactericidal activity against most gram-negative and anaerobic bacteria, including Pseudomonas. Cefepime has similar antibacterial activity, and both are widely used in the ICU as empiric coverage in patients with poten…