Restrictive vs liberal fluid resuscitation in sepsis (CLOVERS trial)

Fluid resuscitation and vasopressors are both usually needed in septic shock, but the ideal volume of fluid to infuse before starting vasopressors has been unclear. In an NHLBI-sponsored trial enrolling 1563 patients at 60 U.S. centers, patients with sepsis and systolic blood pressure <100 mm Hg all received at least 1000 mL of crystalloid. They were th…