Rituximab improved pulmonary alveolar proteinosis in pilot study (Eur Resp J)
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Pulmonary alveolar proteinosis occurs as an idiopathic disease, or can be secondary to other conditions (HIV, silica exposure, infections, blood cancers). In the idiopathic form, autoantibodies to GM-CSF are thought to be responsible. Rituximab (a chimeric mouse-human monoclonal antibody binding CD-20) depletes human B-cells, reducing antibody production. Autoantibodies are particularly reduced after rituximab administration, leading to its successful use in many autoimmune conditions (lupus, rheumatoid arthritis, etc). Kavuru et al asked, why not try rituximab for idiopathic pulmonary alveolar proteinosis?
Rituximab improved pulmonary alveolar proteinosis in pilot study (Eur Resp J)
Rituximab improved pulmonary alveolar…
Rituximab improved pulmonary alveolar proteinosis in pilot study (Eur Resp J)
Pulmonary alveolar proteinosis occurs as an idiopathic disease, or can be secondary to other conditions (HIV, silica exposure, infections, blood cancers). In the idiopathic form, autoantibodies to GM-CSF are thought to be responsible. Rituximab (a chimeric mouse-human monoclonal antibody binding CD-20) depletes human B-cells, reducing antibody production. Autoantibodies are particularly reduced after rituximab administration, leading to its successful use in many autoimmune conditions (lupus, rheumatoid arthritis, etc). Kavuru et al asked, why not try rituximab for idiopathic pulmonary alveolar proteinosis?