Should platelets be transfused in thrombocytopenic patients before central line placement?

In hematologic malignancies, yes; PACER trial provides limited insight otherwise

Central venous catheterization (CVC or central lines), when placed with ultrasound guidance, have a low rate of severe bleeding complications, even in patients with significant thrombocytopenia. Nevertheless, platelets are frequently transfused prior to CVC placement in patients with platelet counts 20,000-50,000/mcL. Is this justified?

The PACER trial r…