Surprise: Bronchoconstriction (not just inflammation) causes airway remodeling in asthma
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Grainge et al collected bronchial biopsies from 48 allergic asthmatics, then randomly gave them either inhaled dust mite allergen; methacholine; saline (control); or albuterol followed by methacholine (control). Those inhaling allergen or methacholine had immediate bronchoconstriction, followed by an increase in bronchial wall thickness (on repeat bronchial biopsy 4 days later) compared to controls. Dogma has it that chronic inflammation, not intermittent bronchoconstriction, induces airway remodeling.
Surprise: Bronchoconstriction (not just inflammation) causes airway remodeling in asthma
Surprise: Bronchoconstriction (not just…
Surprise: Bronchoconstriction (not just inflammation) causes airway remodeling in asthma
Grainge et al collected bronchial biopsies from 48 allergic asthmatics, then randomly gave them either inhaled dust mite allergen; methacholine; saline (control); or albuterol followed by methacholine (control). Those inhaling allergen or methacholine had immediate bronchoconstriction, followed by an increase in bronchial wall thickness (on repeat bronchial biopsy 4 days later) compared to controls. Dogma has it that chronic inflammation, not intermittent bronchoconstriction, induces airway remodeling.