Tenecteplase (TNK) noninferior to alteplase (tPA) for ischemic stroke*

* in China

Tenecteplase is a modified version of tissue plasminogen activator (alteplase), with a higher affinity for binding to fibrin and a longer half-life. TNK can be pushed as a single intravenous bolus, making it easier to administer than alteplase (10% of which is infused over one minute, followed by the other 90% over 60 minutes).

TNK has replaced tPA/alte…