The Latest in Critical Care, 11/27/23 (Issue #20)

Beta-blockers for septic shock? (STRESS-L), vitamin C for Covid-19, corporate takeover of medicine

Nov 27, 2023

∙ Paid

Beta-blockers for septic shock (STRESS-L trial)

Apr 30

Septic shock deranges multiple complex signaling systems in the body. Complement pathways, the “inflammasome” (cytokines, et al), the coagulation cascade, and many, many more systems have been implicated, carefully mapped, with potential molecular targets identified for intervention. After more than 100 randomized trials, no effective therapy has yet resulted (

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Vitamin C for Covid-19 (LOVIT-COVID and REMAP-CAP)

PulmCCM

Apr 30

Vitamin C has a powerful hold on the medical imagination. Much of this can be attributed to Nobel laureate Linus Pauling’s late-career obsession with the molecule. He evangelized as late as 1990 for megadoses that he promised would let us live 25 years longer, “free of diseases.” (Vitamin C is a vital nutrient that prevents scurvy and whose supplementation does seem to

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How are corporations taking over medicine despite laws against it?

To maintain the centrality of physicians in the provision of medical care, and minimize the profit motive to the extent possible, legislators in many states long ago passed laws asserting the corporate-practice-of-medicine (CPOM) doctrine. These laws prohibit non-physicians from ownership…

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