The Latest In Critical Care, 9/23/24 (#57)

Optimal oxygen dose duration; High vs low BiPAP pressures for COPD exacerbations; Assessing for fraud in Chinese clinical trials

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Links:

Ekström M et al; REDOX Collaborative Research Group. Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia. N Engl J Med. 2024 Sep 19;391(11):977-988. doi: 10.1056/NEJMoa2402638. Epub 2024 Sep 10. PMID: 39254466.

Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Nocturnal Oxygen Therapy Trial Group. Ann Intern Med. 1980 Sep;93(3):391-8. doi: 10.7326/0003-4819-93-3-391. PMID: 6776858.

Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. Lancet. 1981 Mar 28;1(8222):681-6. PMID: 6110912.

Hardinge M, et al. British Thoracic Society Home Oxygen Guideline Development Group; British Thoracic Society Standards of Care Committee. British Thoracic Society guidelines for home oxygen use in adults. Thorax. 2015 Jun;70 Suppl 1:i1-43. doi: 10.1136/thoraxjnl-2015-206865. PMID: 25870317.

Anthonisen NR. Prognosis in chronic obstructive pulmonary disease: results from multicenter clinical trials. Am Rev Respir Dis. 1989 Sep;140(3 Pt 2):S95-9. doi: 10.1164/ajrccm/140.3_Pt_2.S95. PMID: 2675713.

Ahmadi Z, Sundh J, Bornefalk-Hermansson A, Ekström M. Long-Term Oxygen Therapy 24 vs 15 h/day and Mortality in Chronic Obstructive Pulmonary Disease. PLoS One. 2016 Sep 20;11(9):e0163293. doi: 10.1371/journal.pone.0163293. PMID: 27649490; PMCID: PMC5029935.

Sundh J, Ahmadi Z, Ekström M. Daily duration of long-term oxygen therapy and risk of hospitalization in oxygen-dependent COPD patients. Int J Chron Obstruct Pulmon Dis. 2018 Aug 28;13:2623-2628. doi: 10.2147/COPD.S167523. PMID: 30214180; PMCID: PMC6118242.

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Luo Z et al; HAPPEN Investigators. Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial. JAMA. 2024 Sep 16:e2415815. doi: 10.1001/jama.2024.15815. Epub ahead of print. PMID: 39283649; PMCID: PMC11406453.

Osadnik CR, Tee VS, Carson-Chahhoud KV, Picot J, Wedzicha JA, Smith BJ. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017 Jul 13;7(7):CD004104. doi: 10.1002/14651858.CD004104.pub4. PMID: 28702957; PMCID: PMC6483555.

Rochwerg B, et al. Members Of The Steering Committee, Antonelli M, et al . Members Of The Task Force. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J. 2017 Aug 31;50(2):1602426. doi: 10.1183/13993003.02426-2016. PMID: 28860265.

Bassler D et al. Stopping Randomized Trials Early for Benefit and Estimation of Treatment Effects: a Systematic Review and Meta-regression Analysis. JAMA 2010

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Retraction Watch

The Truth about China’s Cash-for-Publication Policy, MIT Technology Review, July 2017

“Why Fake Research Is Rampant in China,” The Economist, February 2024

The End of Publish or Perish? China’s New Policy on Research Evaluation, Max Planck Institute

Five ways China must cultivate research integrity, Nature, November 2019

Analysis of doctoral graduates' attitudes toward academic misconduct and its causes, Wangfang Data, 2008

Nearly half of US Chinese student dismissals due to “academic dishonesty”, The PIE, September 2023

Dana-Farberications at Harvard University, For Better Science, January 2024

Landmark research integrity survey finds questionable practices are surprisingly common, Science (blog), July 2021

How Much Scientific Research Is Actually Fraudulent? Reason, July 2021