Tranexamic acid for severe hemorrhage after trauma (PATCH)

An astonishing 2 million people die from bleeding after trauma each year around the world, it is estimated. Tranexamic acid (TXA) is a synthetic analog of the amino acid lysine, which reversibly binds to plasminogen, reducing its fibrinolytic action. Tranexamic acid improved survival after traumatic bleeding in the CRASH-2 trial, but those patients were…