GM-CSF (Leukine) for acute lung injury & ARDS (RCT)
www.pulmccm.org
Human recombinant granulocyte macrophage colony stimulating factor (GM-CSF or Leukine) did not reduce ventilator-days in patients with acute lung injury / ARDS in a randomized trial published in the January 2012 Critical Care Medicine. Why would it have? Interestingly, patients with ARDS with higher levels of GM-CSF in their BAL fluid are more likely to survive. GM-CSF maintains homeostasis in the lung and is required for proper maturation of alveolar macrophages, which are themselves responsible for surfactant clearance/balance and pulmonary innate immunity. GM-CSF also promotes survival and growth of alveolar epithelial cells -- the very cells injured in ARDS. (Actually, I'll stop saying "acute lung injury" -- remember, the expertocracy has informed us there's
GM-CSF (Leukine) for acute lung injury & ARDS (RCT)
GM-CSF (Leukine) for acute lung injury & ARDS…
GM-CSF (Leukine) for acute lung injury & ARDS (RCT)
Human recombinant granulocyte macrophage colony stimulating factor (GM-CSF or Leukine) did not reduce ventilator-days in patients with acute lung injury / ARDS in a randomized trial published in the January 2012 Critical Care Medicine. Why would it have? Interestingly, patients with ARDS with higher levels of GM-CSF in their BAL fluid are more likely to survive. GM-CSF maintains homeostasis in the lung and is required for proper maturation of alveolar macrophages, which are themselves responsible for surfactant clearance/balance and pulmonary innate immunity. GM-CSF also promotes survival and growth of alveolar epithelial cells -- the very cells injured in ARDS. (Actually, I'll stop saying "acute lung injury" -- remember, the expertocracy has informed us there's