How many people with DVT / PE already have HIT antibodies at presentation? (And should we care?)
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Do we need to worry about pre-existing heparin-induced thrombocytopenia antibodies in people admitted with pulmonary embolism / deep venous thrombosis? Or can we keep happily slinging heparin at first sight? Warkentin et al analyze data from the Matisse VTE studies, which enrolled 3,994 patients with DVT or PE. All had ELISA HIT antibodies collected at entry, and 127 (3.2%) were "HIT-positive." (Remember that you are not supposed to do this routinely due to the high false positive rate. Instead, use the 4Ts.) Only 14 of the 127 (0.4% of the 3,994) had the more specific platelet-activating antibodies.
How many people with DVT / PE already have HIT antibodies at presentation? (And should we care?)
How many people with DVT / PE already have…
How many people with DVT / PE already have HIT antibodies at presentation? (And should we care?)
Do we need to worry about pre-existing heparin-induced thrombocytopenia antibodies in people admitted with pulmonary embolism / deep venous thrombosis? Or can we keep happily slinging heparin at first sight? Warkentin et al analyze data from the Matisse VTE studies, which enrolled 3,994 patients with DVT or PE. All had ELISA HIT antibodies collected at entry, and 127 (3.2%) were "HIT-positive." (Remember that you are not supposed to do this routinely due to the high false positive rate. Instead, use the 4Ts.) Only 14 of the 127 (0.4% of the 3,994) had the more specific platelet-activating antibodies.