Patients on continuous renal replacement may need higher beta-lactam doses
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Seyler et al prospectively observed 53 patients with sepsis and renal failure on CRRT. Measured at a single point in time after infusion, the concentrations of Zosyn, Ceftaz, and Cefepime at standard dosing regimens were all deemed suboptimal by the authors. Meropenem performed slightly better.
Patients on continuous renal replacement may need higher beta-lactam doses
Patients on continuous renal replacement may…
Patients on continuous renal replacement may need higher beta-lactam doses
Seyler et al prospectively observed 53 patients with sepsis and renal failure on CRRT. Measured at a single point in time after infusion, the concentrations of Zosyn, Ceftaz, and Cefepime at standard dosing regimens were all deemed suboptimal by the authors. Meropenem performed slightly better.