The Latest In Critical Care, 9/30/24 (#57)

Do thickened liquids help dysphasic patients? TNK vs tPA. New epi nasal spray.

Sep 30, 2022

Drinking liquids with dysphagia: the plot thickens (sorry)

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Sep 28

Drinking liquids with dysphagia: the plot thickens (sorry)

Sometimes it seems like half the ICU revolves around aspiration: accepting patients who’ve just done it, helping others not to, considering it in still others who are deteriorating, etc.

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Tenecteplase (TNK) noninferior to alteplase (tPA) for ischemic stroke*

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Sep 27

Tenecteplase (TNK) noninferior to alteplase (tPA) for ischemic stroke*

Tenecteplase is a modified version of tissue plasminogen activator (alteplase), with a higher affinity for binding to fibrin and a longer half-life. TNK can be pushed as a single intravenous bolus, making it easier to administer than alteplase (10% of which is infused over one minute, followed by the other 90% over 60 minutes).

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New nasal spray epinephrine approved by FDA

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Sep 26

New nasal spray epinephrine approved by FDA

The U.S. FDA approved an epinephrine nasal spray in August, the first nasal spray approved to treat anaphylaxis.

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Physiology Flashback:

ICU Physiology in 1,000 Words: Right Ventricular Afterload (Part 1 of 2)

Jon-Emile S. Kenny

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March 13, 2015

ICU Physiology in 1,000 Words:

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The Thoughtful Intensivist

The Physician’s War

This is my first post about the book “The Physician's War: The Story of the Hidden Battle between Physicians and a Science Based on Pathological Consensus" available at Amazon…

2 days ago · Rafael Olivé Leite

Vinay Prasad's Observations and Thoughts

An overdose of second opinions

A while back, I saw a 65 year old woman with a new diagnosis of multiple myeloma. She was a wealthy, well connected and health literate. She used those connections to pursue 3 different second opinions. At places like Mayo clinic, MD Anderson and MSKCC. Each of the doctors she saw was a "trialist”— the first or last author on a pharmaceutical company…

20 days ago · 240 likes · 41 comments · Vinay Prasad

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