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The Real-World Boards: Question #45

Fevers after a long ICU stay.

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PulmCCM
Jul 31, 2026
∙ Paid

These are the Real-World Boards. As in the real world, there is often no “right” answer, and you are only competing against yourself. Upgrade to the Lifelong Learner level for full access to all the questions and unlimited CME credits with an included Learner+ account.


A 76-year-old woman was admitted with septic shock due to perforated diverticulitis. She underwent emergent laparotomy and hemicolectomy, after which she was transferred to the ICU, where she was mechanically ventilated for nine days. She remains unable to take adequate nutrition enterally and has a central venous catheter in place for parenteral nutrition.

It is now hospital day 12. She has had intermittent fevers for most of the past five days. She has received piperacillin-tazobactam since admission. Blood, urine, and sputum cultures have been negative.

In the past hour, she has become hypotensive, and vasopressors are begun.

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