Transfusing freshest RBC associated with better ICU survival
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In a 5-week prospective observational study in 47 Australian & New Zealand ICUs, Pettila et al (the ANZICS group) followed 757 ICU patients receiving red blood cell transfusions for anemia of any cause. Those in the quartile receiving the youngest RBCs (mean age 7.7 days) had an absolute 8% lower mortality than the other 3 quartiles (13% vs 21%, CI 2.2-14.0), who were transfused 23-day old RBCs, on average. This was before adjusting for any covariates. After adjusting for what they could, the odds ratio for death in the "freshest RBC" quartile was ~0.5 (this was presented as an OR of 2.0 in the 3 "old RBC" quartiles, which sounds scarier).
Transfusing freshest RBC associated with better ICU survival
Transfusing freshest RBC associated with…
Transfusing freshest RBC associated with better ICU survival
In a 5-week prospective observational study in 47 Australian & New Zealand ICUs, Pettila et al (the ANZICS group) followed 757 ICU patients receiving red blood cell transfusions for anemia of any cause. Those in the quartile receiving the youngest RBCs (mean age 7.7 days) had an absolute 8% lower mortality than the other 3 quartiles (13% vs 21%, CI 2.2-14.0), who were transfused 23-day old RBCs, on average. This was before adjusting for any covariates. After adjusting for what they could, the odds ratio for death in the "freshest RBC" quartile was ~0.5 (this was presented as an OR of 2.0 in the 3 "old RBC" quartiles, which sounds scarier).