The Great Lactate Debate Part 2: can we ‘myth-bust’ the strong ion approach?
www.pulmccm.org
Jon-Emile S. Kenny MD [@heart_lung] “The truth is rarely pure and never simple.” -Oscar Wilde In part 1, the crux of this ‘Great Lactate Debate’ was distilled into the unclear origin of the proton in the setting of ‘lactic acidosis.’ Is the [H+] secondary to biochemical work and ATP hydrolysis or is the proton from the addition of a strong anion [i.e. lactate] to the intracellular milieu? Note that this debate is not whether or not lactate can occur when mitochondrial respiration is normal
The Great Lactate Debate Part 2: can we ‘myth-bust’ the strong ion approach?
The Great Lactate Debate Part 2: can we…
The Great Lactate Debate Part 2: can we ‘myth-bust’ the strong ion approach?
Jon-Emile S. Kenny MD [@heart_lung] “The truth is rarely pure and never simple.” -Oscar Wilde In part 1, the crux of this ‘Great Lactate Debate’ was distilled into the unclear origin of the proton in the setting of ‘lactic acidosis.’ Is the [H+] secondary to biochemical work and ATP hydrolysis or is the proton from the addition of a strong anion [i.e. lactate] to the intracellular milieu? Note that this debate is not whether or not lactate can occur when mitochondrial respiration is normal