Updates

Sighs: do they help? (SiVent trial); Delaying intubation in intoxicated patients (NICO trial).
Beta-blockers for septic shock? (STRESS-L), vitamin C for Covid-19, corporate takeover of medicine
Convalescent plasma for severe Covid-19; Cryoprecipitate for massive hemorrhage (CRYOSTAT-2); Aortic balloon occlusion for trauma (UK-REBOA)
Societies call for SEP-1 elimination; Amikacin for VAP (AMIKINHAL trial); Statins for Covid-19 pneumonia (REMAP-CAP trial)
ACORN trial (cefepime vs. pip-tazo), Paxlovid for Omicron, MDROs on the rise
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Jon-Emile Kenny’s collected physiology posts are being added here. Check them out. You can also get Jon’s physiology book off the main menu tab at the…
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Do inhaled steroids improve Covid pneumonia? Systemic corticosteroids (such as intravenous dexamethasone) improve outcomes in severe pneumonia due to…
Can early mobility in the ICU improve cognitive outcomes? Intensive, early mobilization of patients in the ICU seems like it just has to help. Get…
Pulse oximeters overestimated oxygen saturation in darker-skinned patients with Covid, causing treatment delays. It was a bit of a national and…
New Covid variant BA.2.86 turns epidemiologists’ heads. It’s highly mutated (35 mutations on the spike protein; as big a change as Omicron relative to…
High vs. low oxygenation targets in mechanically ventilated patients. Further evidence from the ICONIC trial suggests oxygenation that seems “good…
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New Practice Guidelines for Diagnosis and Management of Acute Respiratory Distress Syndrome As mentioned here previously, a group of U.S. and European…